Working in a field where "actions-per-minute" has a direct correlation with productivity, I imagine a more effective keyboard.
Figure 3. Proof of Concept
This one handed keyboard concept design addresses productivity in two ways:
1. Locating keys used most frequently at the most accessible locations - minimizing time spent between key strokes and finger fatigue.
2. Eliminating re-positioning. Not only does the one-handed utility of this design eliminate the migration of one hand between mouse and keyboard, the size and shape of the board conforms to the natural resting posture of the hand. Furthermore, to enable all keys to be accessible without adjusting the hand to a secondary position, keys located at familiar resting positions are much smaller. This allows more space for keys located in outstretched positions along the board to be much larger (size being dictated by proximity to resting positions).
Figure 2. Data
"English letter frequency (frequency)" by Nandhp - Own work; en:Letter frequency.. Licensed under Public Domain via Commons - https://commons.wikimedia.org/wiki/File:English_letter_frequency_(frequency).svg#/media/File:English_letter_frequency_(frequency).svg
I present the data-set in figure 2 as research that is not my own. This design represents the exploration of data justified form making in lieu of conforming the design of our most used products to precedence and habit. It's not perfect, but it's an idea.